The church is flanked by  the vast complex of former College of Scolopi , which now houses the Artistic Lyceum. The renovation began in 1663, after the release of the buildings used as places of worship which had been banned until that year . The works ended  only in late 1735 because of a long pause for unknown reasons in the first two decades of the 18th century. Restored and reopened to the public after the war, was closed again during the 70s. Since then, due to the endless renovation , the monument is not open and is in a total state of disrepair.

The building has significant differences in comparison with the previous places of worship  in Cagliari , probably for the Scolopi's will to fulfill the functions of popular education , as well as worship. This characteristic does not exclude the twin resemblance with almost all the other  Scolopi's buildings in the rest of Italy , often unchanging except for a few details in the inside, influenced by the local culture.The church, in Baroc Style, shows a harmonious main façade with a terminal plate , punctuated by pilasters of Ionic's capital. The portal is surmounted by a cornice broken curve tympanum, with the Scolopi's coat of arms in the inside.

The interior has a single nave with a barrel vault , with three communicating chapels for  every side and  a deep chancel covered by a dome on an octagonal tambour. It has often been noted that the technical approach is similar to the Dome of Cagliari.

The temple was decorated with many artworks, some of which are unfortunately lost ,  while others  are currently stored in various churches in the city . Into the church, is still possible to see  the imposing altar , date back to 1777 ,  by the sculptor Giovanni Battista Franco ,  in polychrome marble, and the marble pulpit date back to the same period . The last chapel ,on the right side, contains one of the bombs dropped on the College in 1793 , during the siege of the French, who tried to conquer the city , accompanied by a commemorative stone of the event. The vestry is decorated with attractive wooden furniture and murals that represent the foundation of the Scolopi's  order.

The Church of Saint Giuseppe is located in via Toti, in Pirri. Erected in the 1950s, the works ended after eight years in 1966. The style of the building is characterized by simple lines combined with geometric shapes. Embellished with a stone path, flower beds and palm trees, on the facade there are three wooden doors surmounted by an ogival-shaped opening. The interior instead is characterized by a division into three naves with the central one raised compared to the side ones.

The Church of Saint Giovanni Battista is located in the Villanova district, in via San Giovanni and hosts the seat of the Archconfraternity of Solitude, active in the organization of some suggestive rites related to Holy Week. Probably erected around the fifteenth century it underwent restoration and the current facade, in neo-Romanesque style, dates back to the twentieth century. The portal is surmounted by a frescoed lunette depicting Saint John the Baptist intent on playing with a lamb, a symbol of Christ.

The Church of Saint Giacomo is one of the parish priests of the Villanova district and overlooks the homonymous square. It was probably built around the middle of the fourteenth century as reported by an ordination of the councilors of Castello and represents an important testimony of the Catalan Gothic architecture in the city. It was restored between the eighteenth and nineteenth centuries and the current facade, the work of the architect Gaetano Cima, presents stylistic features typical of the neoclassical language.

The Church of Saint Francesco da Paola is also known by the name of San Francesco al Molo. Located along via Roma and in front of the port, it is officiated by the minimum friars who dedicated the title to the founder of the religious order since 1907. According to tradition, the saint performed a miracle freeing Cagliari from the terrible drought of 1739. The facade in style Classic dates back to 1932 and the lower part has a portico with three round arches. Inside stands a sumptuous late eighteenth century altar by the artist Giovanni Battista Spazzi.

The Church of Saint Francesco d'Assisi overlooks via Piemonte, in the La Vega district. Entrusted to the conventual friars who live in the nearby convent, the title is dedicated to the famous religious from Assisi. Built between the fifties and sixties of the twentieth century on a project by the engineer Marco Piloni, it has a dark stone facade decorated with a polychrome glass window.

The Church of Saint Domenico is located in the homonymous square, one of the most characteristic and popular places in the Villanova district. The church is officiated by the Dominican friars who live in the nearby convent. The first plant of the building constituted an important testimony of the Catalan Gothic architecture present in the city but was destroyed by the bombings of 1943. Above its remains the new church was built between 1952 and 1954 and the direction of the works entrusted to the Florentine architect Raffaello Fagnoni. The external facade in white limestone is flanked by a high bell tower.

The Church of Saint Cesello overlooks via San Giovanni, in the Villanova district. It was built in 1702 thanks to the funds donated by the Gremio dei Bottai. The members wanted to create a chapel as the headquarters of the association and chose the place that until the nineteenth century housed the Porta Cabanes, an important link between the neighborhood and the Campidano countryside. The simple facade is decorated with an ogival arch and a small sail bell tower stands out above.

The Church of Saint Carlo Borromeo overlooks the homonymous street. The title is dedicated to the cardinal and archbishop, venerated as a saint and considered one of the greatest reformers of the Church in the sixteenth century. The building was built using reinforced concrete and polychrome stone for the closures. The external facade is characterized by exposed stone in square blocks and the bell tower covered with bricks stands out.

The Church of San Benedetto or the Good Shepherd is located in the San Benedetto district, an area of ​​Cagliari that experienced intense urban development in the first half of the twentieth century. The temple and the adjoining convent were erected in 1643 by the will of a nobleman of Genoese origin Don Benedetto Nater who wanted to donate them to the Capuchin friars. The friars lived here until 1885 when the convent closed following the entry into force of the law to suppress religious orders. The facade reproduces elements of the Aragonese Gothic style especially in the portal surmounted by two oculi. The interior develops with a simple barrel-vaulted nave and hosts a wooden sculpture of the dead Christ dating back to the seventeenth century.